Hematology in Practice 2nd Edition By Betty Ciesla – Test Bank
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Sample
Test
Chapter 3: Red Blood Cell Production, Function, and Relevant Red
Blood Cell Morphology
Multiple Choice
Identify the choice that best completes the statement or answers
the question.
____
1. The
erythrocyte stage that marks the beginning of hemoglobinization is called:
1. Basophilic
normoblast
2. Polychromatophilic
normoblast
3. Orthochromic
normoblast
4. Pronormoblast
____
2. One of the
key morphological features of the nucleated red cell stages is:
1. Basophilic
cytoplasm through every stage of maturation
2. Granules
in the cytoplasm
3. A
round nucleus
4. An
increase in size as the cell matures
____
3. The red
cell protein that is responsible for deformability and flexibility of the red
cell is:
1. Spectrin
2. Glycophorin
3. Glycine
4. EPO
____
4. Increased
plasma cholesterol may lead to the development of which of these abnormal red
cell morphologies?
1. Spherocytes
2. Target
cells
3. Microcytes
4. Helmet
cells
____
5. Which of
the following RBC pathways is responsible for providing 90% of the cellular ATP
for red cell metabolism?
1. Embden-Meyerhof
pathway
2. Methemoglobin
reductase pathway
3. Rapoport-Luebering
pathway
4. Hexose
monophosphate shunt
____
6. The
hemoglobin molecule consists of:
1. One
heme molecule, one globin chain
2. One
heme molecule, four globin chains
3. Two
heme molecules, two globin chains
4. Four
heme molecules, four globin chains
____
7. The basic
pathophysiology of the thalassemic conditions is a/an:
1. Decreased
or absent globin chain synthesis
2. Absence
of iron absorption
3. Failure
to incorporate iron into the pronormoblast
4. Side
effect of iron overload
____ 8.
Asynchrony in the bone marrow is defined as the:
1. Presence
of nucleoli throughout each maturation phase
2. Presence
of extremely basophilic cytoplasm in all precursors
3. Lack
of nuclear development in precursor cells
4. Nuclear
development and hemoglobin development that is unbalanced
____
9.
Polychromatophilic macrocytes in the peripheral smear are most likely:
1. Siderocytes
2. Reticulocytes
3. Spherocytes
4. Pappenheimer
bodies
____
10. The red cell
inclusion derived from denatured hemoglobin are:
1. Howell-Jolly
bodies
2. Pappenheimer
bodies
3. Heinz
bodies
4. Siderotic
granules
____
11. The degree of
effective erythropoietic activity in any hematological disorder is most readily
assessed by a/an:
1. Red
cell count
2. Reticulocyte
count
3. M:E
ratio
4. Hemoglobin
determination
____
12. When hemolysis is
produced by the intravascular fragmentation of red cells, which red cell
morphology will be produced?
1. Spherocytes
2. Macrocytes
3. Acanthocytes
4. Schistocytes
____
13. Most hypochromic
cells will have an MCHC that is:
1. Greater
than 36%
2. Less
than 30%
3. Greater
than 27%
4. Less
than 27%
____
14. Reversible sickled
cells are described as having a:
1. Crescent
shape with one pointed projection
2. Crescent
shape with two pointed projections
3. Half-moon
shape with rounded ends
4. Half-moon
shape with pointed projection
____
15. The last nucleated
stage of erythrocytic maturation is the:
1. Pronormoblast
2. Orthochromic
normoblast
3. Polychromatophilic
normoblast
4. Basophilic
normoblast
____
16. Red cell inclusions
that are remnants of DNA are termed:
1. Cabot
rings
2. Howell
Jolly bodies
3. Heinz
bodies
4. Pappenheimer
bodies
____
17. From each
pronormoblast precursor cell, _____ mature red blood cells are produced.
1. 4
2. 8
3. 12
4. 16
____
18. Pappenheimer bodies
are composed of:
1. Iron
2. Denatured
hemoglobin
3. DNA
4. RNA
____
19. Describe the
hemoglobin content of the cell at the end of the pointer.
1. Normochromic
2. Hypochromic
3. Polychromatophilic
4. Hyperchromic
____
20. Identify the cell at
the end of the pointer.
1. Spherocyte
2. Schistocyte
3. Acanthocyte
4. Normocyte
____
21. Identify the cell at
the end of the pointers.
1. Reticulocyte
2. Spherocyte
3. Sickle
cell
4. Target
cell
____
22. The term used to
describe the inclusions seen in the cell at the end of the pointer is (Wright’s
stain):
1. Pappenheimer
bodies
2. Basophilic
stippling
3. Howell
Jolly bodies
4. Siderotic
granules
True/False
Indicate whether the statement is true or false.
____
23. The higher the N:C
ratio, the more mature the cell.
____
24. The anucleate mature
red blood cell has no ability to produce protein.
Chapter 3: Red Blood Cell Production, Function, and Relevant Red
Blood Cell Morphology
Answer Section
MULTIPLE CHOICE
1. ANS:
B
PTS: 1
2. ANS:
C
PTS: 1
3. ANS:
A
PTS: 1
4. ANS:
B
PTS: 1
5. ANS:
A
PTS: 1
6. ANS:
D
PTS: 1
7. ANS:
A
PTS: 1
8. ANS:
D
PTS: 1
9. ANS:
B
PTS: 1
10. ANS:
C
PTS: 1
11. ANS:
B
PTS: 1
12. ANS:
D
PTS: 1
13. ANS:
B
PTS: 1
14. ANS:
C
PTS: 1
15. ANS:
B
PTS: 1
16. ANS:
B
PTS: 1
17. ANS:
D
PTS: 1
18. ANS:
A
PTS: 1
19. ANS:
C
PTS: 1
20. ANS:
A
PTS: 1
21. ANS:
D
PTS: 1
22. ANS:
B
PTS: 1
TRUE/FALSE
23. ANS:
F
PTS: 1
24. ANS:
T
PTS: 1
Chapter 4: Hemoglobin Function and Principles of Hemolysis
Multiple Choice
Identify the choice that best completes the statement or answers
the question.
____ 1. What percentage of
hemoglobin is synthesized in the reticulocyte stage?
|
a. |
65% |
|
b. |
95% |
|
c. |
35% |
|
d. |
45% |
____ 2. Epsilon and zeta chains
are part of which of the following hemoglobins?
|
a. |
Hemoglobin Portland |
|
b. |
Hemoglobin F |
|
c. |
Hemoglobin A |
|
d. |
Hemoglobin A2 |
____ 3. Fetal hemoglobin consists
of which of the following chains?
|
a. |
a2b2 |
|
b. |
a2g2 |
|
c. |
a2d2 |
|
d. |
a2e2 |
____ 4. The hemoglobin molecule
will either hold onto or release oxygen depending on the:
|
a. |
Amount of alpha or beta
chains |
|
b. |
Relationship between the
pulmonary and venous circulations |
|
c. |
Viscosity of the blood |
|
d. |
M:E ratio |
____ 5. Which of the following
abnormal hemoglobins will result in a cyanotic condition?
|
a. |
Sulfhemoglobin |
|
b. |
Cyanmethemoglobin |
|
c. |
Hemoglobin F |
|
d. |
Hemoglobin M |
____ 6. What is the term used to
define the process by which the bone marrow responds to anemia-induced stress?
|
a. |
Ineffective erythropoiesis |
|
b. |
Aplastic anemia |
|
c. |
Erythroid hyperplasia |
|
d. |
Medullary erythropoiesis |
____ 7. Which of the following
factors will result in an immediate increase in oxygen delivery to the tissues?
|
a. |
Increased pH |
|
b. |
Increased altitude |
|
c. |
Increased 2,3-DPG |
|
d. |
Increased carboxyhemoglobin |
____ 8. How many genes are
responsible for the productions of alpha chains?
|
a. |
Two |
|
b. |
One |
|
c. |
Three |
|
d. |
Four |
____ 9. Which of the following
clinical conditions is a definitive sign of intravascular lysis?
|
a. |
Bilirubinemia |
|
b. |
Decreased RBC count |
|
c. |
Hemoglobinuria |
|
d. |
Elevated LDH |
____ 10. Which organ(s) is the most affected
during extravascular lysis?
|
a. |
Liver and spleen |
|
b. |
Kidney |
|
c. |
Pancreas |
|
d. |
Heart |
____ 11. Each hemoglobin molecule consists of
____ heme structures.
|
a. |
two |
|
b. |
four |
|
c. |
six |
|
d. |
eight |
____ 12. Physiologic conditions in the body
that can decrease hemoglobin’s oxygen affinity include:
|
a. |
Increased pH |
|
b. |
Decreased 2,3-DPG |
|
c. |
Increased body temp |
|
d. |
The presence of abnormal
hemoglobins |
____ 13. When iron is present in an oxidized
state, as Fe+3 or ferric iron, the resulting hemoglobin is known as:
|
a. |
Methemoglobin |
|
b. |
Carboxyhemoglobin |
|
c. |
Sulfhemoglobin |
|
d. |
Deoxyhemoglobin |
____ 14. ________ may be seen in intravascular
hemolysis but not in extravascular hemolysis.
|
a. |
Hemoglobinuria |
|
b. |
Splenomegaly |
|
c. |
Increased LDH |
|
d. |
Elevated serum bilirubin |
____ 15. Intrinsic red cell defects that can
lead to hemolysis include:
|
a. |
Environmental effects |
|
b. |
Inherited deficiencies |
|
c. |
A shift in pH |
|
d. |
A decrease in G6PD |
____ 16. Which of the following is not an
embryonic hemoglobin?
|
a. |
Hgb Portland |
|
b. |
Hgb F |
|
c. |
Hgb Gowers I |
|
d. |
Hgb Gowers II |
True/False
Indicate whether the statement is true or false.
____ 17. Hemoglobin begins to be synthesized
at the polychromatophilic stage of red cell development.
____ 18. Abnormal hemoglobins have a lower affinity
for oxygen.
____ 19. 90% of in vivo hemolysis is
intravascular.
____ 20. Oxygen delivery is the primary
purpose of hemoglobin.
Chapter 4: Hemoglobin Function and Principles of Hemolysis
Answer Section
MULTIPLE CHOICE
1. ANS:
C
PTS: 1
2. ANS:
A
PTS: 1
3. ANS:
B
PTS: 1
4. ANS:
B
PTS: 1
5. ANS:
D
PTS: 1
6. ANS:
C
PTS: 1
7. ANS:
C
PTS: 1
8. ANS:
A
PTS: 1
9. ANS:
C
PTS: 1
10. ANS:
A
PTS: 1
11. ANS:
B
PTS: 1
12. ANS:
C
PTS: 1
13. ANS:
A
PTS: 1
14. ANS:
A
PTS: 1
15. ANS:
B
PTS: 1
16. ANS:
B
PTS: 1
TRUE/FALSE
17. ANS:
T
PTS: 1
18. ANS:
F
PTS: 1
19. ANS:
F
PTS: 1
20. ANS:
T
PTS: 1
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